An integrated metabolomic and proteomic approach for the identification of covalent inhibitors of the main protease (Mpro) of SARS-COV-2 from crude natural extractsArticle Published on 2023-01-152022-11-15 Journal: Talanta [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Analysis applied approach baicalein binding carried catalytic characteristic Chinese complementary complex Compound Covalent binder Cys145 database drug target electrophilic Final functional HIS163 HIS164 His41 independent inhibitor inhibitors Ion knowledge M pro M(pro) mass mass spectrometry maturation metabolomic metabolomics Michael molecular dynamics MPro nucleophilic peptide platform polyprotein protease protein-ligand Proteins proteomic proteomics residue SARS-CoV-2 SARS-CoV-2. Scutellaria baicalensis tested the SARS-CoV-2 [DOI] 10.1016/j.talanta.2022.123824 PMC 바로가기
Understanding the impact of rapid antigen tests on SARS-CoV-2 transmission in the fifth wave of COVID-19 in Hong Kong in early 20222022년 초 홍콩에서 COVID-19의 5번째 물결에서 SARS-CoV-2 전파에 대한 신속한 항원 검사의 영향 이해Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] addition Analysis Antigen case fatality ratio confirmed case confirmed cases COVID-19 decrease disease transmission effective examined Government highlight home quarantine Hong Kong implementation mass measure omicron outbreak rapid antigen test Rapid antigen tests Region Reproduction number rising SARS-CoV-2 SARS-CoV-2 transmission suggested superspreading. the disease understanding variant of SARS-CoV-2 [DOI] 10.1080/22221751.2022.2076616 PMC 바로가기 [Article Type] Article
Immunogenicity and reactogenicity after heterologous prime-boost vaccination with CoronaVac and ChAdox1 nCov-19 (AZD1222) vaccinesCoronaVac 및 ChAdox1 nCov-19(AZD1222) 백신으로 이종 프라임-부스트 백신 접종 후 면역원성 및 반응성Article Published on 2022-11-302022-09-12 Journal: Human vaccines & immunotherapeutics [Category] MERS, 진단, [키워드] 95% CI 95% confidence interval Administered age age and sex antibody assigned AZD1222 binding domain booster dose Care ChAdOx1 nCoV-19 Cohort cohorts Combination Concentration control group CoronaVac COVID-19 COVID-19 pandemic effective elicited enrolled finding geometric mean ratio GMR Health Heterologous heterologous prime-boost homologous immune response immunogenicity indicated mass participant primary endpoint prime-boost interval RBD reactogenicity robust Safe the median vaccination Vaccine vaccine administration vaccine combination. while [DOI] 10.1080/21645515.2022.2052525 PMC 바로가기 [Article Type] Article
A Robust, Highly Multiplexed Mass Spectrometry Assay to Identify SARS-CoV-2 VariantsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome Care characterized circulation Clinical studies collected coronavirus defined Delta demonstrated diagnostic diagnostic capability effort functional health system health systems identify increasingly Infection prevention Iota Laboratory MALDI-TOF mass molecular MOST multiplex New York City omicron Panel Patient Patient care polymorphism Population public health measures public health systems RNA robust RT-PCR SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant seeking sensitivity specificity specimen Spectrometry Surveillance target tested Transmissibility USA utility vaccination variant variant call variant panel. virus WGS while whole-genome sequencing [DOI] 10.1128/spectrum.01736-22 PMC 바로가기
The impact of COVID-19 on implementation of mass testing, treatment and tracking of malaria in rural communities in Ghana: A qualitative studyArticle Published on 2022-10-132022-11-15 Journal: PLoS ONE [Category] 진단, [키워드] addition affected analysed Analysis children Community Complication conducted Coverage COVID-19 COVID-19 pandemic Effect eight English finding group Health health worker identify implementation increase in Intervention introduced malaria mass methodology observation pandemic parent participant public health respond responsible Transcription translated treat Treatment Volunteer volunteers was used were recorded [DOI] 10.1371/journal.pone.0275976 PMC 바로가기
Estimates of SARS-CoV-2 Omicron BA.2 Subvariant Severity in New EnglandArticle Published on 2022-10-032022-11-16 Journal: JAMA Network Open [Category] COVID19(2023년), SARS, 변종, [키워드] 30-Day mortality 95% CI accounted adjusted adjusted odds ratio Admission Admissions age Analysis appear applied approach assigned B.1.1.529 B.1.617.2 cohort study confirmed COVID-19 case confounders confounding factor COVID-19 Delta delta variant England estimate Factor Hospitalization infections intensive care intrinsic intrinsically invasive ventilation less Lineage Longitudinal data mass Mortality multicenter New occurred omicron outcome outcomes retrospective cohort study risk SARS-CoV-2 secondary severity significantly Vaccinations variant variants variety were excluded with COVID-19 women [DOI] 10.1001/jamanetworkopen.2022.38354 PMC 바로가기
Mass Switch From Intravenous to Subcutaneous Tocilizumab in Rheumatic Diseases During the SARS-COV-2 PandemicArticle Published on 2022-10-012022-11-15 Journal: Journal of clinical rheumatology : practical reports on rheumatic & [Category] COVID19(2023년), SARS, 진단, [키워드] administration adverse event Analysis Cell COVID Critical disease effective Follow-up Giant giant cell arteritis headache hospital injection intravenous juvenile idiopathic arthritis mass pandemic Patient remained rheumatoid arthritis rheumatological patient rheumatology Safe Subcutaneous subgroup analysis switch switching Systemic sclerosis TCZ the SARS-CoV-2 Tocilizumab Treatment was performed [DOI] 10.1097/RHU.0000000000001862 PMC 바로가기
Validation of a duplex PCR technique using the gen E and RNase P for the diagnosis of SARS-CoV-2Article Published on 2022-10-012022-11-16 Journal: Enfermedades infecciosas y microbiologia clinica ( [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis Berlin protocol Charité clinical samples COVID-19 COVID-19 diagnosis Cribado masivo Diagnosis diagnosis of SARS-CoV-2 Diagnóstico E gene English Faculty of Medicine Genes independent Laboratory limit of detection limitations mass Mass screening no significant difference not affect PCR PCR en tiempo real polymerase chain protocol reagent real time Real-time PCR reduce reliability reported reproducibility reverse transcriptase RNA sample RNase P RT-PCR SARS-CoV-2 SARS-CoV-2. sensitivity Sensitivity and specificity similarity Spanish specificity specimen threshold validation World Health Organization [DOI] 10.1016/j.eimce.2022.05.005 PMC 바로가기
Spectroscopic methods for COVID-19 detection and early diagnosisArticle Published on 2022-09-222022-11-15 Journal: Virology Journal [Category] SARS, 치료기술, [키워드] caused coronavirus Coronavirus infection COVID-19 diagnosis of COVID-19 Early detection early diagnosis FIVE Fluorescence Fluorescence spectroscopy increase individual Infection infrared infrared spectroscopy limitation mass mass spectrometry pandemic Raman spectroscopy Raman spectroscopy. reduce reported SARS-CoV-2 Spread virus Weekly World Health Organization Wuhan, China [DOI] 10.1186/s12985-022-01867-2 PMC 바로가기
A How to Guide: Clinical Population Test Development and Authorization of MALDI-ToF Mass Spectrometry-Based Screening Tests for Viral InfectionsArticle Published on 2022-09-032022-11-15 Journal: Viruses [Category] 치료기술, [키워드] applied Applying Asymptomatic asymptomatic screening authorization Bacteria Bacterial CLIA CLIA-LDT clinical clinical process clinical testing COVID-19 criteria detection development diagnostic fungi Infection Laboratory limits MALDI-TOF MS mass MS test overcome pathogenic Population Population screening Proteins regulatory authority SAR-CoV-2 SARS-CoV-2 Screening Systems biology Test viral infection Viral infection. viral infections Viral protein virus virus viruses [DOI] 10.3390/v14091958 PMC 바로가기